In this case review, we follow a 49-year-old male patient through a remarkable complication chain — from a gastric wall abscess to a giant incisional ventral hernia. The initial CT demonstrated a 5 cm thick-walled lesion in the gastric wall with central fluid and surrounding inflammatory fat stranding. Although it initially mimicked a neoplastic lesion such as a Gastrointestinal stromal tumor, pathology revealed dense inflammatory infiltration with multinucleated giant cells, confirming a gastric abscess. Three months later, a subcutaneous seroma developed in the epigastric region. Five months after the seroma — and eight months after the initial surgery — the patient presented with a large anterior abdominal wall defect. CT imaging showed: An 11 cm transverse fascial defect 19 cm craniocaudal extension Small bowel loops herniating into the subcutaneous tissue Findings were consistent with a giant Incisional hernia. This case highlights a classic post-inflammatory and postoperative complication sequence: Abscess → Seroma → Hernia Understanding this progression is crucial for radiologists, surgeons, and trainees involved in abdominal imaging and postoperative follow-up